Destabilization of simple repetitive DNA sequences by transcription in yeast.
نویسندگان
چکیده
Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.
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ورودعنوان ژورنال:
- Genetics
دوره 143 2 شماره
صفحات -
تاریخ انتشار 1996